Variable Control of Ets-1 DNA Binding by Multiple Phosphates in an Unstructured Region
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چکیده
منابع مشابه
Variable control of Ets-1 DNA binding by multiple phosphates in an unstructured region.
Cell signaling that culminates in posttranslational modifications directs protein activity. Here we report how multiple Ca2+-dependent phosphorylation sites within the transcription activator Ets-1 act additively to produce graded DNA binding affinity. Nuclear magnetic resonance spectroscopic analyses show that phosphorylation shifts Ets-1 from a dynamic conformation poised to bind DNA to a wel...
متن کاملUnstructured Region Variable Control of Ets - 1 DNA Binding by Multiple Phosphates
, 142 (2005); 309 Science et al. Miles A. Pufall Unstructured Region Variable Control of Ets-1 DNA Binding by Multiple Phosphates in an This copy is for your personal, non-commercial use only. clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Permiss...
متن کاملMiles A . Pufall , Phosphates in an Unstructured Region Variable Control of Ets - 1 DNA Binding by Multiple
http://www.sciencemag.org/cgi/content/full/309/5731/142 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/309/5731/142/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http://w...
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15 صفحه اولPhosphorylation represses Ets-1 DNA binding by reinforcing autoinhibition.
Phosphorylation of transcription factors is a key link between cell signaling and the control of gene expression. Here we report that phosphorylation regulates DNA binding of the Ets-1 transcription factor by reinforcing an autoinhibitory mechanism. Quantitative DNA-binding assays show that calcium-dependent phosphorylation inhibits Ets-1 DNA binding 50-fold. The four serines that mediate this ...
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ژورنال
عنوان ژورنال: Science
سال: 2005
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.1111915